Ibuprofen

Maddie Millward Block D

IBUPROFEN

__Chemical name:__ 2-(4-isobutylphenyl) propanoic acid __Chemical formula:__ C 13 H 18 O 2

__Structure:__



__Creation of Ibuprofen:__ The original method for creating ibuprofen was developed by Boots researchers and begins with 2-methylpropylbenzene which can be made from compounds separated from crude oil. Then there is a six step process to add, remove and transport atoms. This first process is very wasteful and not efficient. There have been other methods developed to create 2-(4-isobutylphenyl) propanoic acid. One example of a different method is one invented by green chemists. This method also starts with 2-methylpropylbenzene but is less wasteful by using different catalysts and fewer steps. Green chemistry is the practice of making chemical compounds that are less wasteful of raw materials, more sensitive to environmental concerns, and less hazardous to human health. How It Affects Us:

__Uses:__ Ibuprofen has analgesic (pain-relieving) and antipyretic (fever-reducing) properties. Ibuprofen is used as a non-steroidal anti-inflammatory to relieve mild or moderate pain. It is commonly found in households to relieve mild pains and headaches. Ibuprofen is a very helpful drug that has little to no side affects, other than relieving pain of course. It is also used for the treatment of acute and chronic rheumatoid arthritis and osteoarthritis. It is extremely affective in controlling pain in one’s muscles and joints.

__Harms:__ The main risk associated with ibuprofen is stomach irritations. Some people may be highly sensitive or take high doses may cause damage to their stomach lining. Other people who take high doses have complaints of stomach pains and/or nausea. In very high doses ibuprofen can raise ones risk of life threatening heart or circulation problems. Also, if you are a smoker, it is best to talk with a doctor before taking ibuprofen even in small amounts as it may cause problems with the lungs or circulation. Ibuprofen was created to have less gastrointestinal affects than aspirin or other common pain relievers, and it is successful in having few harsh side effects when used properly. The most common reason for any problems with ibuprofen is an overdose of the drug. The maximum dose of ibuprofen for adults is 800mg per dose or 3200mg per day (4 doses).

__Discovered and put on the market:__ Ibuprofen was discovered in the 1950‘s by Dr. Stewart Adams and his colleagues in the UK. It was patented in 1961, and was made available to the public in 1969. Before it became available in the United States in 1974, people would sell this pain reliever ‘under the table’ with the code names Advil and Motrin. These are now the names of huge companies that distribute ibuprofen to pharmacies and drug stores around the world.

__Interesting Fact:__ Ibuprofen is used for some treatments for Alzheimer's disease. Alzheimer’s disease is a brian disorder also known as dementia. It was estimated to affect 26.6million people worldwide in 2006. The disease takes many years to develop in each individual and is different in every case but they are common affects of the disease on a person. Alzheimer’s disease causes the brain to very slowly shut down, patients lose their memories, short and long-term, and they forget everything about their lives and themselves until eventually, the brain forgets how to function the body and the patient dies. The disease starts after the age of 65 and some patients live for fourteen years after diagnoses, average survival after diagnoses is seven years. Ibuprofen has ben researched to reduce one’s risk of Alzheimers disease after only two years. Ibuprofen, as an organic compound, can fight off the risk of Alzheimer’s disease from reaching the brain. When Alzheimer’s was first discovered, and still today, doctors and scientists know that the disease is uncurable, but it can be prevented (in many people) with a regular dose of ibuprofen.

Sources: Ibuprofen:

Chemical name and formula: [|__http://www.albemarle.com/TDS/Pharmaceuticals/SC5001F_Ibuprofen.pfd__] Structure: 2D - [|__http://www.medsafe.govt.nz/profs/datasheet/b/brufentabpic1.gif__] 3D - [|__http://www.chemistryinyourcupboard.org/images/nurofen/figure6-large.jpg__] Discovery and put on the market: [|__http://www.chemistryexplained.com/Hy-Kr/Ibuprofen.html__] Making of Ibuprofen: [|__http://www.rsc.org/education/teachers/learnnet/green/ibuprofen/home.htm__] [|__http://www.bookrags.com/research/2-4-isobutylphenylpropionic-acid-chmc/__] Harms: [|__http://www.drugs.com/ibuprofen.html__] Interesting Fact Info: [|__http://www.chemistryinyourcupboard.org/images/nurofen/figure6-large.jpg__] [|__http://www.sciencedaily.com/releases/2008/05/080505162913.htm__] __[| http://www.ncbi.nlm.nih.gov/pubmed/12804498]__ Other Info: [|__http://www.medicinenet.com/ibuprofen/article.htm__]  [|__http://en.wikipedia.org/wiki/Ibuprofen__]